High Incidence of Recurrent EBV Infection Found in CFS

For years the controversary over whether or not EBV was the cause or related to CFS has continued to be researched.

Back in 2006. a clinical study showed that 100% of the patients studied (58) had evidence of prior EBV exposure and 72% had evidence for reactivated EBV infection. The study also showed that 94% of the patients studies had B-cell immunodeficiency with a marked depletion of their CD19+IgM+ mature B-lymphocyte population.

The study also found that 81% of the CFS patients in the study experienced some improvement of their symptoms once they were treated with folinic acid.

So the initial theory that there is a high incidence of severe B-cell immunodeficiency and chronic reactivated Epstein-Barr virus (EBV) infection in patients with CFS was found to be correct.